Recently, cannabidiol (CBD), a non-psychoactive compound from Cannabis sativa, has garnered attention for its therapeutic potential. Neuroprotection, one of its potential health benefits, has garnered attention. Neuroprotection protects neurons, the nervous system’s building blocks. CBD’s neuroprotective properties have led researchers to investigate its use in neurodegenerative diseases like Alzheimer’s and Parkinson’s. CBD and neuroprotection are complex, and more research is needed to understand their mechanisms and benefits.
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CBD interacts with the endocannabinoid system (ECS), a complex signaling network that regulates physiological processes, including nervous system functions. CBD does not cause the cannabis “high” like tetrahydrocannabinol (THC). CBD affects the ECS to promote neuroprotection.
Antioxidant and anti-inflammatory properties may help CBD protect neurons. CBD’s ability to reduce oxidative stress and inflammation may protect neurons from damage. CBD reduces brain oxidative damage and inflammation in neurodegenerative disease animal models.
CBD may protect the brain’s signaling systems and receptors. The compound interacts with brain receptors like CB1, CB2, serotonin, and TRPV1. These receptors promote neurogenesis, neuroprotection, and neurotransmitter release.
CBD may improve brain health in neurodegenerative diseases. Neuron loss and cognitive decline characterize Alzheimer’s and Parkinson’s diseases. Researchers hope CBD’s neuroprotective properties will help treat these diseases rather than just managing symptoms.
CBD reduces amyloid-beta plaques in Alzheimer’s disease animal models. Amyloid-beta plaques may damage neurons and impair cognition. CBD may slow disease progression and protect brain cells by reducing their formation.
CBD may also slow neurodegeneration in Parkinson’s. CBD may protect motor-functioning dopaminergic neurons, which are affected in Parkinson’s disease. CBD’s anti-inflammatory and antioxidant properties may reduce neuronal degeneration.
Despite promising preclinical data, translating CBD’s neuroprotective effects to humans is difficult. CBD neurodegenerative disease trials are scarce. To prove CBD’s neuroprotective efficacy, large-scale, well-designed clinical trials are needed due to the complexity of these diseases and individual responses to CBD.
CBD’s neuroprotective effects are being studied in neurological conditions other than neurodegenerative diseases. CBD may help epilepsy. Epidiolex, a CBD-based medication, is FDA-approved for treating severe epilepsy in children. Epidiolex shows CBD’s neurological disorder treatment potential.
