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Epilepsy, which causes recurrent seizures, affects millions worldwide. Many antiepileptic drugs (AEDs) fail to control seizures or cause side effects. Thus, cannabidiol (CBD) is a promising alternative treatment.
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Cannabis produces non-psychoactive CBD. Its therapeutic potential, particularly in epilepsy management, garnered attention. After a series of well-publicized cases of children with severe epilepsy experiencing significant seizure frequency and severity reductions, CBD for seizure management gained popularity.
Dravet syndrome, a severe form of epilepsy, affected Charlotte Figi, a young girl. Charlotte’s parents tried CBD oil after conventional treatments failed. Charlotte’s seizures decreased, resulting in the CBD-rich “Charlotte’s Web” strain for epilepsy.
Charlotte’s success inspired epilepsy patients and their families to research CBD’s efficacy and safety. CBD has been tested for seizure management in several clinical trials.
The FDA approved Epidiolex, a purified CBD oral solution, to treat Lennox-Gastaut syndrome (LGS) and Dravet syndrome in 2018. Epidiolex became the first FDA-approved cannabis-derived medication.
Researchers have proposed several mechanisms for CBD’s antiepileptic effects. CBD may affect the endocannabinoid system, which regulates physiological processes like neural excitability. CBD may reduce seizure-causing neuronal firing by modulating this system.
CBD’s effect on adenosine receptors is another possibility. Adenosine, an antiepileptic neurotransmitter, inhibits neural activity. CBD inhibits adenosine reuptake, making the brain more inhibitory.
CBD may not be a cure-all for epilepsy, despite strong evidence. Some studies show mixed results, and not all patients improve. CBD response depends on epilepsy type, dosage, and individual variability.
CBD may also alter AED metabolism and cause side effects. Thus, patients should consult their doctors before using CBD.
CBD has fewer side effects than conventional AEDs. CBD causes diarrhea, fatigue, and appetite changes, while AEDs cause cognitive impairments, drowsiness, and liver toxicity.
CBD’s long-term safety needs research. Its long-term risks are unknown because it is a new treatment. Long-term studies are needed to determine CBD’s safety and any potential side effects.
Patients seeking CBD treatment face legal issues in many countries. Cannabis stigma has limited funding and regulatory barriers for research.
As CBD’s efficacy grows, attitudes and regulations may change, allowing more research and better access for patients.
Finally, CBD may treat epilepsy. Success stories and scientific evidence have excited doctors and patients. CBD’s relatively mild side effects make it an appealing alternative or adjunctive therapy for those who don’t respond well to conventional AEDs.
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Researchers must approach CBD’s therapeutic potential with optimism and caution. By maximizing its benefits and acknowledging its drawbacks, we can improve epilepsy patients’ quality of life and advance seizure management.
